Subsets of Lupus Patients Identified by Gene Expression Profiles Exhibit Differential Clinical Responsiveness to Baricitinib
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The authors aimed to identify subsets of systemic lupus erythematosus (SLE) patients that exhibit differential clinical responsiveness to baricitinib, a JAK1 inhibitor. Through transcriptomic analysis of 272 patients, they identified eight molecular endotypes, with significant clinical responses to baricitinib observed in endotypes D and G. The study highlights that treatment-responsive subsets were not identifiable through clinical features alone, emphasizing the importance of gene expression profiles in predicting therapeutic outcomes.
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