Identification of Novel Non-coding Genetic Variants of Serum Urate Using Whole Genome Sequencing in 7,339 Chinese
Listen to this summary
The authors aimed to investigate the genetic architecture of low-frequency and rare variants associated with serum urate (SU) levels in East Asian populations, specifically focusing on their implications for gout and cardiometabolic diseases. Through whole-genome sequencing of 7,339 Han Chinese participants, they identified novel male-specific loci and rare variants that may influence SU regulation, enhancing understanding of the genetic factors contributing to SU levels and potential targets for precision therapies.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Arthritis & rheumatology (Hoboken, N.J.)
View all →Mar 25, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Per- and polyfluoroalkyl substances and knee osteoarthritis: data from the Osteoarthritis Initiative
Mar 25, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From the Phase 2a, Multicenter, Randomized, Double-Blind, Proof-of-Concept AFFINITY Study
Mar 23, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Validation of International Classification of Diseases (ICD) code-based case definitions of immune checkpoint inhibitor associated inflammatory arthritis from administrative health data
Mar 23, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Subsets of Lupus Patients Identified by Gene Expression Profiles Exhibit Differential Clinical Responsiveness to Baricitinib
Mar 19, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Functional Impact of Structural Damage in Psoriatic Arthritis: Insights from a Prospective Cohort Study
Mar 19, 2026 · Arthritis & rheumatology (Hoboken, N.J.)
A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still's Disease-like Autoinflammatory Syndrome
More in Internal Medicine
View all →Mar 25, 2026 · Gastroenterology
From Autoimmunity to Intestinal Tissue Damage: Insights From Potential Celiac Disease as a Paradigm of Disease Progression
Mar 25, 2026 · The American journal of sports medicine
Deltoid Osteomuscular Transfer Suppresses Humeral Head Translation Caused by Massive Irreparable Rotator Cuff Tears: A Cadaveric Biomechanical Study
Mar 25, 2026 · The American journal of medicine
Antiphospholipid Antibodies among Hospitalized Patients Predict Mortality and Readmission: A Real-World 10-Years Cohort Study
Mar 25, 2026 · British journal of sports medicine
Injury risk and its relationship with biological maturation among 100 junior tennis athletes: a 15-year retrospective analysis
Mar 25, 2026 · The American journal of medicine
Evaluation of Patients Presenting to a Multidisciplinary Lymphatic Center
Mar 25, 2026 · The American journal of medicine
Pathophysiology, Diagnosis, and Management of Cervical Disc Herniation
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
