Per- and polyfluoroalkyl substances and knee osteoarthritis: data from the Osteoarthritis Initiative

The authors aimed to investigate the relationship between specific per- and polyfluoroalkyl substances (PFAS) and the incidence of knee osteoarthritis (KOA) as well as knee pain progression in a cohort from the Osteoarthritis Initiative. They found that higher serum concentrations of perfluorooctanoic acid and perfluorononanoic acid were associated with an increased likelihood of developing symptomatic KOA and experiencing knee pain progression. These findings suggest a potential link between PFAS exposure and adverse knee health outcomes.