Telocyte Deletion is Associated with Loss of Lymphatic Drainage and Exacerbation of Inflammatory-Erosive Arthritis in Mice
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The authors investigate the role of telocytes in lymphatic drainage and inflammatory-erosive arthritis using transgenic mice models. They find that the depletion of telocytes leads to impaired lymphatic function and worsens joint pathology in zymosan-induced arthritis, suggesting that telocytes are crucial for maintaining synovial lymphatic system integrity and may serve as potential therapeutic targets for rheumatoid arthritis.
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