Pyrotinib or placebo in combination with trastuzumab and docetaxel for HER2 positive metastatic breast cancer: long term survival results from randomised phase 3 PHILA trial
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The authors of the phase 3 PHILA trial aimed to evaluate the efficacy and safety of pyrotinib, in combination with trastuzumab and docetaxel, compared to placebo in patients with untreated HER2 positive metastatic breast cancer. The updated results demonstrated that the pyrotinib regimen significantly improved both progression-free survival and overall survival, while maintaining a consistent safety profile. These findings support the use of this dual anti-HER2 treatment strategy as an effective initial therapy for this patient population.
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