Camrelizumab plus CAPOX with camrelizumab based maintenance versus CAPOX alone as initial treatment for gastric or gastro-oesophageal junction adenocarcinoma: randomised phase 3 trial
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This phase 3 trial aimed to compare the effectiveness of camrelizumab combined with capecitabine and oxaliplatin (CAPOX) followed by maintenance therapy with either apatinib or camrelizumab against CAPOX alone in patients with HER2-negative, unresectable gastric or gastro-oesophageal junction adenocarcinoma. The results indicated that the camrelizumab-based regimens significantly improved overall survival compared to CAPOX alone, although no additional survival benefit was observed when apatinib was added during maintenance, and higher rates of severe treatment-related adverse events were noted.
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