Accuracy of glomerular filtration rate estimation based on creatinine and cystatin C for monitoring moderate chronic kidney disease in adults: prospective, longitudinal cohort study

The authors aimed to evaluate the longitudinal accuracy of glomerular filtration rate (GFR) estimating equations that incorporate both creatinine and cystatin C for monitoring moderate chronic kidney disease (CKD) in adults. Their findings indicate that dual biomarker equations provided better agreement with measured GFR changes compared to those based solely on creatinine, although all equations exhibited poor sensitivity for detecting disease progression. The study suggests that incorporating both biomarkers in clinical practice could enhance monitoring and management of CKD.