Low-dose mifepristone for the management of refractory heavy menstrual bleeding in women with bleeding disorders: a retrospective study

This study aimed to evaluate the effectiveness of low-dose mifepristone as a treatment for refractory heavy menstrual bleeding (HMB) in women with bleeding disorders, particularly those with thrombocytopenia or on antithrombotic therapy. The findings indicated significant improvements in bleeding control, with a majority of patients achieving amenorrhea and no serious safety concerns reported. The authors suggest that mifepristone may be a viable bridge therapy for this patient population, warranting further prospective studies.