Biological/targeted synthetic DMARDs do not arrest bone loss in patients with rheumatoid arthritis: a long-term multicenter observational study
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This study aimed to investigate the long-term effects of biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) on bone mineral density (BMD) in patients with rheumatoid arthritis (RA). Despite improvements in clinical disease activity, the findings revealed that b/tsDMARDs did not prevent the progression of osteoporosis, as BMD decreased significantly in patients not receiving osteoporosis treatment, highlighting the need to address osteoporosis independently from RA management.
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