November 4, 2026 · The New England journal of medicine · DOI: 10.1056/NEJMoa2610014

Plozasiran for Severe Hypertriglyceridemia and Risk of Pancreatitis.

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Researchers asked whether plozasiran, an siRNA therapy that silences APOC3 mRNA, can lower triglycerides and reduce acute pancreatitis risk in adults with severe hypertriglyceridemia. In two pooled, double-blind, placebo-controlled trials of 757 patients, plozasiran cut median triglycerides by about 79-81% from baseline at 12 months, versus placebo. Acute pancreatitis occurred at 1 versus 5 per 100 patient-years, with a rate ratio of 0.22 (P = 0.008), suggesting a meaningful reduction in pancreatitis risk.

Gerald F Watts, Christie M Ballantyne, Agustin Blanco Echevarria, Jamie Smith, Robert S Rosenson, Savitha Subramanian, James Trippi, Norman Lepor, Archna Bajaj, Vladimir Blaha, Russell Scott, Alexis Baass, Ira J Goldberg, Antonio Gallo, Jose Luis Diaz, Manish Saxena, Jianping Li, Rong Zhou, Lalitha Aiyer, Jennifer Hellawell, James Hamilton, Daniel Gaudet

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Plozasiran for Severe Hypertriglyceridemia and Risk of Pancreatitis.

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