November 2, 2026 · The New England journal of medicine · DOI: 10.1056/NEJMoa2607326

TAVR in Patients with Moderate Aortic Stenosis with At-Risk Features.

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Current guidelines recommend only clinical surveillance for patients with moderate aortic stenosis, but it is unknown whether transcatheter aortic-valve replacement (TAVR) improves outcomes in those with at-risk features. In this international randomized trial of 744 patients, transfemoral TAVR was superior to surveillance for reducing death or heart-failure events at 2 years (16.7% vs. 23.9%, risk difference -7.2 percentage points, P = 0.02), driven mainly by fewer heart-failure events, with no meaningful difference in all-cause mortality.

Philippe Généreux, Raj R Makkar, Philippe Pibarot, Jeroen J Bax, Brian R Lindman, Kamran Muhammad, J Bradley Oldemeyer, Mark Pirwitz, Colin M Barker, Vinod H Thourani, Pradeep K Yadav, Roberto Rodriguez, Justin Strote, Rahul Sakhuja, Ramzi Khalil, Rahul Sharma, Adnan Chhatriwalla, Jacob M Mishell, Biswajit Kar, Sameer Gafoor, Joseph Walsh, Daniel Spoon, Andrew Frutkin, Andrei Pop, Nicolas M Van Mieghem, Ruby Satpathy, Kenji Ando, Joseph Montarello, John Webb, Sreekanth Vemulapalli, David J Cohen, Aakriti Gupta, Brandon Park, Heather Prince, Philipp Blanke, Michael Mack, Martin B Leon

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TAVR in Patients with Moderate Aortic Stenosis with At-Risk Features.

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