November 2, 2026 · The New England journal of medicine · DOI: 10.1056/NEJMoa2610771

Coronary CT Angiography versus Intravascular Ultrasound Guidance for PCI.

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This randomized noninferiority trial asked whether PCI planned with coronary CT angiography (CCTA) is as safe and effective as IVUS-guided PCI in 1,105 patients with stable revascularization indications and CCTA-derived FFR of 0.80 or less. At 12 months, target-vessel failure occurred in 4.1% of the CCTA-guided group versus 4.6% of the IVUS-guided group, meeting the noninferiority criterion (risk difference -0.42 points, margin 4.5 points). CCTA-guided PCI was therefore noninferior to IVUS-guided PCI for target-vessel failure, though superiority was not shown.

Carlos Collet, Takuya Mizukami, Frederic Bouisset, Gianluca Pontone, Carlo Zivelonghi, Daniel A Jones, Adriaan Wilgenhof, Nicolaj Brejnholt Støttrup, Bálint Szilveszter, Kaoru Tanaka, Gianluca Mincione, Yader Sandoval, Ian Purcell, James C Spratt, Divaka Perera, Niels Thue Olsen, Tetsuya Amano, Peter O'Kane, Simone Biscaglia, Hasan Jilaihawi, Ziad Ali, Eric Van Belle, Richard Good, Taito Arai, Brian Ko, Jeroen Sonck, Alan Bagnall, Timothy Fairbairn, Antonio Bartorelli, Giulio Stefanini, Jonathon Leipsic, Thomas Engstrøm, Bjarne Linde Nørgaard, Bernard De Bruyne, Bruno R da Costa, Daniele Andreini

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Coronary CT Angiography versus Intravascular Ultrasound Guidance for PCI.

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