Biphasic CT clustering-based habitat radiomics predicts WHO/ISUP nuclear grade in clear cell renal cell carcinoma

The authors aimed to evaluate the effectiveness of a biphasic CT clustering-based habitat radiomics approach in predicting the WHO/ISUP nuclear grade of clear cell renal cell carcinoma (ccRCC) by analyzing different tumor subregions. Their findings indicate that specific subregions, particularly the tumor viable-necrosis transition zone, can provide diagnostic performance comparable to whole-tumor assessments. The study suggests that this method could enhance non-invasive characterization of ccRCC, although further validation is required before clinical application.