Melatonin, circadian metabolism, mitochondrial remodeling, and cell size dynamics in primitive hematopoietic stem cells

The authors investigate how circadian rhythms and melatonin influence the metabolic state and functionality of primitive hematopoietic stem cells (pHSCs). They demonstrate that nocturnal melatonin levels trigger mitochondrial remodeling and metabolic reprogramming, enhancing pHSCs' regenerative capacity through increased glycolytic activity and structural adaptations. This study highlights the importance of circadian cues in maintaining stem cell fitness and suggests potential clinical implications for hematopoietic stem cell transplantation.