September 21, 2026 · Critical care medicine · DOI: 10.1097/CCM.0000000000007335

Epilepsy After Antipsychotic Prescription in Survivors of Traumatic Brain Injury: A Population-Based Cohort Study

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The authors aimed to determine whether the choice of antipsychotic medication following hospitalization for traumatic brain injury (TBI) is linked to the risk of developing post-traumatic epilepsy in older adults. Their retrospective cohort study found no significant difference in epilepsy risk between those prescribed haloperidol or risperidone compared to quetiapine, although high mortality rates in the cohort may affect the reliability of these findings. Further research is suggested to confirm these results.

Augusto Ferraris, Alejandro G Szmulewicz, Neill K J Adhikari, Lisa Burry, Alejandro Hernández, Hannah Wunsch, Damon C Scales, Federico Angriman

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