Epidemiology of Critically Ill Patients With Cirrhosis Undergoing Continuous Renal Replacement Therapy: A Contemporaneous Parallel Analysis of the HRS-HARMONY and CRRTnet Registries

The authors aimed to describe the epidemiology and clinical processes of continuous renal replacement therapy (CRRT) in critically ill patients with cirrhosis or acute-on-chronic liver failure (ACLF). They found that higher prescribed CRRT doses were associated with increased in-hospital mortality, and a significant portion of survivors were transitioned to intermittent hemodialysis before discharge. Overall, the study highlights the high mortality rates in this patient population and the common use of citrate anticoagulation despite potential risks.