African-specific variants at the GATM locus and genetic bias in creatinine-based GFR estimation

The authors investigate how African-specific variants at the GATM locus contribute to biases in creatinine-based estimated glomerular filtration rate (GFR) assessments. They identify a variant that increases creatine synthesis and serum creatinine levels in individuals of African ancestry, providing a biological explanation for discrepancies in GFR estimation that are not related to actual kidney function.