September 15, 2026 · Radiology · DOI: 10.1148/radiol.260238

Opportunistic Chest CT Paraspinal Muscle Biomarkers to Predict Longitudinal Thoracic Vertebral Bone Mineral Density Loss: Results from MESA

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The authors aimed to determine whether CT-derived metrics of paraspinal muscle, specifically attenuation and volume, can independently predict longitudinal loss of thoracic vertebral bone mineral density (BMD) in an aging population. Their findings indicate that lower muscle attenuation is a significant predictor of BMD loss and incident vertebral fractures, suggesting that paraspinal muscle characteristics could serve as valuable biomarkers in assessing bone health.

Quincy A Hathaway, Elena Ghotbi, Tommy Pan, Sara Momtazmanesh, Joshua G Klein, Matthew Allison, Eduardo J Mortani Barbosa, R Graham Barr, David A Bluemke, João A C Lima, Wendy Post, Geoffrey H Tison, Bharath Ambale-Venkatesh, Matthew Budoff, Shadpour Demehri

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