Evaluating the Effect of Neighborhood-level Disadvantage on Brain Health: An Imaging Epidemiology Study

This study investigates the relationship between neighborhood-level socioeconomic disadvantage, as measured by the Area Deprivation Index (ADI), and brain health in a clinical population. The authors found that residing in more disadvantaged neighborhoods was associated with adverse brain morphometric outcomes, including an increased brain age gap, reduced total brain volume, and elevated white matter hyperintensity volume. These findings highlight the potential impact of neighborhood disadvantage on brain health, emphasizing its relevance for public health and clinical practice.