September 12, 2026 · American journal of obstetrics & gynecology MFM · DOI: 10.1016/j.ajogmf.2026.102116

Perinatal outcomes in individuals with co-occurring anxiety and/or depression and substance use in pregnancy

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This study investigates the impact of co-occurring anxiety and/or depression and substance use during pregnancy on maternal and neonatal outcomes. The authors found that individuals with both mental health disorders and substance use, particularly stimulants or opioids, experienced significantly higher risks of adverse maternal and neonatal outcomes compared to those with anxiety/depression alone. The findings underscore the need for targeted interventions to address these high-risk pregnancies.

Sarena Hayer, Erin C Nacev, Bharti Garg, Kelly M Abshire, Aaron B Caughey, Jamie O Lo

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