September 12, 2026 · American journal of ophthalmology · DOI: 10.1016/j.ajo.2026.09.008

ENDOTHELIAL KERATOPLASTY IN EYES WITH PREVIOUS GLAUCOMA SURGERY: A SYSTEMATIC REVIEW AND META-ANALYSIS STRATIFIED BY GRAFT TECHNIQUE

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The authors aimed to evaluate graft survival, endothelial cell loss, and complication rates following endothelial keratoplasty (EK) in eyes with prior glaucoma surgery, comparing outcomes between Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK). Their systematic review and meta-analysis revealed that only 50% of eyes with prior glaucoma drainage device (GDD) implantation retained a functioning graft at 36 months, with DSAEK showing a numerical advantage in graft survival, particularly in GDD eyes. The study highlights the need for prospective registries with standardized endpoints to better guide clinical decision-making.

Cristina Irigoyen-Bañegil, Macarena Jiménez-Alfaro, Miguel Naveiras, Marina Rodriguez-Calvo-de-Mora

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