September 11, 2026 · Resuscitation · DOI: 10.1016/j.resuscitation.2026.111304

Intravenous or Intraosseous Vascular Access in Cardiac Arrest: An Individual Participant Data Meta-Analysis

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The authors aimed to compare the effectiveness of intraosseous-first versus intravenous-first vascular access during out-of-hospital cardiac arrest by conducting an individual participant data meta-analysis of randomized trials. Their analysis, which included data from 7,561 patients, found no statistically significant differences in 30-day survival, favorable neurological outcomes, or sustained return of spontaneous circulation between the two access methods. Overall, the findings suggest that both approaches yield similar outcomes in this critical setting.

Mathias J Holmberg, Keith Couper, Lars W Andersen, Ranjit Lall, Asger Granfeldt, Chen Ji, Gavin D Perkins, Mikael Fink Vallentin

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