September 11, 2026 · Resuscitation · DOI: 10.1016/j.resuscitation.2026.111306

Association between the first post-resuscitation partial pressure of arterial carbon dioxide and neurologic outcomes in children with out-of-hospital cardiac arrest: a multicenter retrospective cohort study

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The authors aimed to investigate the association between the first post-resuscitation partial pressure of arterial carbon dioxide (PaCO₂) and 30-day neurologic outcomes in children who experienced out-of-hospital cardiac arrest (OHCA). Their multicenter retrospective study found no clear evidence that either hypocapnia or hypercapnia was independently associated with favorable neurologic outcomes or 30-day survival. Despite the lack of significant findings, the study provides insights into the prognostic significance of PaCO₂ levels in this pediatric population.

Nanae Kikuchi, Shunsuke Amagasa, Taro Moriwaki, Keiichi Tomita, Masahiro Kashiura, Yuki Kishihara, Hideto Yasuda, Satoko Uematsu

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