September 9, 2026 · JACC. Clinical electrophysiology · DOI: 10.1016/j.jacep.2026.09.001

High-Voltage Focal PFA Catheter for "Instant" Point-By-Point Ablation: The First-In-Human FIELD-PULSE Trial to Treat AF

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The authors aimed to evaluate the safety and efficacy of a novel high-voltage focal pulsed-field ablation (PFA) catheter designed for "instantaneous" point-by-point ablation in patients with atrial fibrillation. The results demonstrated successful pulmonary vein isolation in all patients with efficient ablation times and high durability of lesions, supporting the potential of this technology for individualized treatment without prolonged catheter stability. The study indicates promising outcomes for the continued clinical development of this instantaneous focal PFA workflow.

Vivek Y Reddy, Jan Petru, Jacob S Koruth, Moritoshi Funasako, Jan Skoda, Jonathan A Salas, Steven R Mickelsen, Petr Neuzil

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