September 8, 2026 · Radiology · DOI: 10.1148/radiol.254050

Histotripsy for Hepatocellular Carcinoma: From Bench to Bedside

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This review examines the development and clinical application of histotripsy, a noninvasive ultrasound ablation technique for treating hepatocellular carcinoma (HCC). The authors aim to highlight histotripsy's advantages over traditional thermal ablation methods, including its ability to precisely destroy tumors while preserving surrounding structures and its potential for enhanced immune response. With FDA approval achieved in October 2023, the review discusses the promising outcomes of clinical trials and the technology's future applications in cancer treatment.

Susu Luo, Xingyu Wei, Xinyu Lu, Zhenguang Wang, Jinmin Zhang, Zhenlun Li, Xin Li, Hui Liu

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