MRI-guided versus OSEM Amyloid Brain PET Reconstruction for Reader Agreement, Visual Consistency, and Diagnostic Accuracy

The authors aimed to determine whether MRI-guided brain PET reconstruction enhances inter-reader agreement, visual consistency, diagnostic accuracy, and quantitative separation of amyloid status compared to the traditional OSEM reconstruction method. Their findings indicate that MRI-guided reconstruction significantly improved inter-reader agreement and specificity, reducing false positives while maintaining effective separation between amyloid-negative and amyloid-positive groups.