August 31, 2026 · Annals of internal medicine · DOI: 10.7326/ANNALS-26-03185-JC

In SLE, adding dapirolizumab pegol vs. placebo to usual care improved disease activity at 48 wk

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The authors investigate whether the addition of dapirolizumab pegol to usual care can improve disease activity in patients with systemic lupus erythematosus (SLE) over a 48-week period. The findings indicate that dapirolizumab pegol significantly enhances disease activity compared to placebo, suggesting its potential as an effective treatment option for SLE.

Francisco R Lafita, Ami Schattner, ACP Journal Club Editorial Team at McMaster University

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