August 31, 2026 · Journal of the American College of Cardiology · DOI: 10.1016/j.jacc.2026.08.034

Stent Retriever Thrombectomy in Patients With Myocardial Infarction The Open-label, Multicenter NATURE Superiority trial

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The authors aimed to determine whether stent-retriever thrombectomy, in addition to conventional percutaneous coronary intervention (PCI), reduces infarct size in patients with ST-segment elevation myocardial infarction and large thrombus burden. The study found that patients receiving stent-retriever thrombectomy had significantly lower infarct sizes compared to those undergoing conventional PCI alone, with no major adverse cardiovascular events reported in the stent-retriever group at 3 days and only one at 30 days. These results suggest that stent-retriever thrombectomy may be a beneficial intervention for this high-risk patient population.

Marco Valgimigli, Enrico Frigoli, Antonio Landi, Marco Covani, Simone Biscaglia, Florim Cuculi, Andrea Erriquez, Matthias Bossard, Antonio Mangieri, Martijn Meuwissen, Juan F Iglesias, Giuseppe Sangiorgi, Erik Lipšic, Jacopo Andrea Oreglia, Jonas D Häner, Valeria Paradies, Anna Giulia Pavon, Laura Anna Leo, Felice Gragnano, Federico Fuentes, Vincenzo Viccaro, Antonio Colombo, Sanda Branca, Sergio Leonardi, Hector M Garcia-Garcia, NATURE Investigators

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