Association Between Age-Dependent DNA Methylation Changes at <em>FKBP5</em> Enhancer Sites and Increased Cortical Gene Expression in Schizophrenia

The authors investigate the relationship between age-dependent DNA methylation changes at the FKBP5 enhancer sites and gene expression in the context of schizophrenia and other psychiatric disorders. They find that lower DNA methylation levels in the FKBP5 proximal enhancer correlate with increased gene expression and are influenced by age and genetic factors, particularly in individuals with schizophrenia. This study highlights the potential epigenetic mechanisms linking FKBP5 expression to psychiatric conditions and aging.