September 1, 2026 · The American journal of psychiatry · DOI: 10.1176/appi.ajp.20260362

New Horizons in the Development of Treatments for Substance Use Disorders

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The authors investigate the urgent need for new treatment options for substance use disorders (SUDs), highlighting significant gaps in current therapies, particularly for cannabis, cocaine, and methamphetamine use disorders. They emphasize the limitations of existing behavioral treatments and advocate for innovative interventions, including new drug classes and delivery methods, to improve the effectiveness and accessibility of SUD treatments.

John J Mariani, Frances R Levin

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