Fibroblast-derived Spondin-2 promotes dysplastic transition in metaplastic gastric epithelial cells
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The authors investigate the role of fibroblast-derived factors in the transition from metaplasia to dysplasia in gastric epithelial cells, identifying Spondin-2 (SPON2) as a key mediator of this process. Through various techniques, including single-cell RNA sequencing and spatial transcriptomics, they demonstrate that SPON2 promotes dysplastic changes in metaplastic gastroids, highlighting its potential as a significant factor in early gastric carcinogenesis. Ultimately, the study positions SPON2 as the first identified fibroblast-derived factor that drives pre-neoplastic progression in gastric epithelium.
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