Faecalibacterium prausnitzii EXL01 Strain for the prevention of multiple-recurrent Clostridioides difficile Infection
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The authors aimed to evaluate the efficacy of the Faecalibacterium prausnitzii EXL01 strain in preventing recurrent Clostridioides difficile infection (rCDI) by restoring microbiome functions. In a murine model and a phase I clinical trial with adults who had multiple CDI episodes, EXL01 demonstrated safety and a high rate of recurrence-free patients, suggesting its potential as a precision microbiome therapeutic. The study highlights the importance of targeting microbiome function rather than solely focusing on taxonomic diversity in treating rCDI.
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