Medicines for children and young people who seek support around gender: a horizon scanning study of the emerging medicines pipeline

The authors aim to identify and analyze the current landscape of clinical trials evaluating medicines for children and young people experiencing gender incongruence or dysphoria. Their horizon scanning study reveals that while there are ongoing trials, many lack rigorous designs, such as control groups and random allocation, which limits their potential to provide meaningful evidence on the effectiveness and safety of these treatments. The authors conclude that future studies with robust methodologies are necessary to fill existing evidence gaps.