Clinically significant night-to-night variability in overnight oximetry screening for obstructive sleep apnoea in children with Down syndrome: a retrospective review of screening data

The authors aimed to investigate the extent and implications of night-to-night variability (NTNV) in overnight oximetry screening for obstructive sleep apnoea (OSA) in children with Down syndrome. Their retrospective review of screening data revealed that over half of the studies exhibited clinically significant NTNV, suggesting that single-night screenings may overlook children who would test positive for OSA on multiple nights. The findings indicate a need to reconsider UK screening guidelines to better account for NTNV and the high prevalence of OSA in older children.