WISP1 Drives Intestinal Fibrosis in Crohn's Disease via Metabolic and Rho/ROCK/MRTF-mediated cytoskeletal Remodeling
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This study investigates the role of WISP1 in driving intestinal fibrosis in Crohn's disease by examining its effects on fibroblast activation, metabolic reprogramming, and extracellular matrix remodeling. The authors found that WISP1 is highly expressed in fibrotic tissues and promotes a shift in fibroblast metabolism that contributes to fibrosis through the RHO/ROCK/MRTF pathway. Neutralizing WISP1 in a murine model reduced fibrosis and inflammation, suggesting it could be a viable target for antifibrotic therapies in Crohn's disease.
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