Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest: The ICECAP Randomized Clinical Trial

The ICECAP randomized clinical trial aimed to determine the optimal duration of therapeutic hypothermia at 33 °C for maximizing neurological recovery in comatose survivors of out-of-hospital cardiac arrest. The study found that increasing the duration of cooling did not improve neurological outcomes, with a posterior probability suggesting that a 6-hour duration may be optimal. Overall, no significant differences in secondary outcomes or mortality were observed across varying cooling durations.