Addition of High-Dose Vitamin D3 to Standard Treatment in Patients With Metastatic Colorectal Cancer: The SOLARIS Randomized Clinical Trial (Alliance A021703)
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The SOLARIS trial aimed to determine whether high-dose vitamin D3, when added to standard chemotherapy, improves outcomes in patients with previously untreated metastatic colorectal cancer (mCRC). The study found that high-dose vitamin D3 did not significantly enhance progression-free survival compared to standard-dose vitamin D3, nor did it show improvements in overall survival or response rates. Overall, the addition of high-dose vitamin D3 did not provide clinically meaningful benefits in this patient population.
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