Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial
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This randomized clinical trial aimed to determine whether initiating dapagliflozin one day prior to elective cardiac surgery could reduce the incidence of acute kidney injury (AKI) within the first week post-surgery. The results showed that dapagliflozin significantly decreased AKI rates compared to placebo (28% vs. 52%), suggesting its potential as a preventive treatment in this patient population. Adverse events such as atrial fibrillation and reoperation rates were similar between the two groups.
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