August 5, 2026 · JACC. Clinical electrophysiology · DOI: 10.1016/j.jacep.2026.06.013

Subcutaneous Implantable Cardioverter-Defibrillator Therapy in Women

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This study aimed to evaluate sex-related differences in outcomes among recipients of subcutaneous implantable cardioverter-defibrillators (S-ICDs), focusing on baseline characteristics, appropriate shocks, complications, reinterventions, and mortality. The findings revealed that women had a lower risk of appropriate shocks and all-cause mortality compared to men, but experienced a distinct complication profile, including higher rates of chronic pain and lead dislodgment. These results underscore the importance of considering sex-specific factors in S-ICD selection and management.

Rodrigue Garcia, Fawzi Kerkouri, Christelle Marquié, Mina Ait Said, Frédéric Anselme, Warda Aoudjeghout, Nicolas Badenco, Marc Badoz, Sergio Barra, Olivier Barthez, Hugues Blangy, Pierre Bordachar, Laure Champ-Rigot, Stéphane Combes, Pascal Defaye, Jean Claude Deharo, Estelle Gandjbakhch, Edouard Gitenay, Hervé Gorka, Isabelle Heurtebise, Jérôme Hourdain, Laurence Jesel, Lila Khris, Alain Lebon, Christophe Leclercq, Sophie Le Page, Alexis Mechulan, Pierre Mondoly, Jean-Luc Pasquié, David Perrot, Bertrand Pierre, Olivier Piot, Anne Quentin, Eric Rendu, Olivier Villejoubert, Victor Waldmann, Orianne Weizman, Vincent Probst, Serge Boveda, Eloi Marijon, HONEST Investigators

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