Association between PCSK9 targeted therapy and the risk of stroke and dementia: A Meta-Analysis of Randomized Controlled Trials
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The authors aimed to investigate the association between PCSK9-targeted therapies and the risk of stroke and dementia by analyzing data from randomized controlled trials. Their meta-analysis, which included 22 trials with over 64,000 patients, found that these therapies significantly reduced the risk of all-cause and ischemic stroke, but did not show a significant impact on the risk of hemorrhagic stroke, transient ischemic attack, or dementia-related conditions. Overall, while PCSK9 therapies may lower stroke risk, they do not appear to influence the risk of dementia or Parkinson's disease.
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