August 5, 2026 · The American journal of medicine · DOI: 10.1016/j.amjmed.2026.07.038

Do Clinical Trials Adequately Serve Clinical Practitioners?

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The authors investigate whether clinical trials effectively serve the needs of clinical practitioners by examining how various factors, such as study design and patient eligibility, affect the applicability of trial results to individual patient care. They highlight the importance of careful interpretation of trial outcomes and propose questions for clinicians to consider when integrating trial findings with patient-specific characteristics and preferences. Ultimately, the review aims to bridge the gap between clinical trial results and real-world clinical practice.

James A Reiffel, Peter R Kowey, Mohammed Hussein Kamareddine, Gerald V Naccarelli

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