July 28, 2026 · The Journal of bone and joint surgery. American volume · DOI: 10.2106/JBJS.26.00723

An International Expert Consensus Statement Defining the Best Practices and Areas of Uncertainty Concerning the Use of Orthobiologics

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The authors aimed to establish an international expert consensus on best practices and uncertainties regarding the use of orthobiologics in musculoskeletal medicine. Through a Delphi study involving 24 experts, they developed and refined 77 statements, ultimately achieving high consensus on many applications of orthobiologics, particularly regarding platelet-rich plasma (PRP) therapies. However, the study highlighted ongoing uncertainties in preparation, dosing, and efficacy, indicating a need for standardization in these areas.

Kyle N Kunze, Jacob T Morgan, Cameron Gerhold, Tanner Nishioka, Nicolas S Piuzzi, Jorge Chahla, Delphi Study Group

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