July 28, 2026 · Radiology · DOI: 10.1148/radiol.252433

Contrast-enhanced Mammography for Breast Cancer Screening in Women at Increased Risk: Comparison of Prevalence and Incidence Screens

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The authors aimed to compare the performance of contrast-enhanced mammography (CEM) between prevalence and incidence screens in women at increased risk for breast cancer. The study found no significant difference in cancer detection rates between the two types of screens, but incidence CEM demonstrated higher specificity and accuracy compared to prevalence CEM. Overall, CEM remained effective in detecting cancers during both screening types, with consistent performance in identifying malignancies.

Carol H Lee, Tali Amir, Varadan Sevilimedu, Sarah Eskreis-Winkler, Delia Keating, Donna D'Alessio, Maxine S Jochelson, Gordon P Watt, Kimberly N Feigin, Noam Nissan, Hila Fruchtman-Brot, Christopher E Comstock, Janice S Sung

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