Is ultrasonic speed of sound estimation for liver fat quantification affected by measurement depth?

The authors aimed to investigate whether the measurement depth affects ultrasonic speed of sound (SS) estimates used for quantifying liver fat in patients with metabolic dysfunction-associated steatotic liver disease. Their findings indicate that SS measurements significantly differ between depths of 4 cm and 6 cm, particularly in patients with high body mass index (BMI) and skin to liver capsule (SLC) distance, suggesting that measurement depth should be considered for the standardization of this technique.