July 27, 2026 · JAMA · DOI: 10.1001/jama.2026.12117

Multidomain Intervention for Growth in Term Small-for-Gestational-Age Infants: A Randomized Clinical Trial

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This study aimed to evaluate the effectiveness of a multidomain intervention package on the growth and neurodevelopment of term small-for-gestational-age (SGA) infants compared to usual care. The results indicated that the intervention significantly improved weight, weight-for-age z scores, and cognitive outcomes, while also reducing the prevalence of underweight, stunting, wasting, and anemia among the infants. Overall, the integrated intervention demonstrated beneficial effects on both physical growth and neurodevelopmental outcomes in this vulnerable population.

Ranadip Chowdhury, Rukman Manapurath, Ravi Prakash Upadhyay, Ingvild Fossgard Sandøy, Saijuddin Shaikh, Harish Chellani, Abhinav Jain, Neeta Dhabhai, Savita Sapra, Afreen Khan, Tarun Shankar Choudhary, Kiran Bhatia, Jose Martines, Nita Bhandari, Tor A Strand, Sunita Taneja, Small Babies Trial Study Group

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