Peptide Therapeutics in Orthopaedics: Current Evidence and Future Directions
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The authors explore the current landscape and future potential of peptide therapeutics in orthopaedics, focusing on their design principles and clinical applications. They highlight the evolution from naturally occurring peptides to engineered synthetics, such as teriparatide and PLG0206, while addressing the challenges in achieving clinical validation for disease-modifying osteoarthritis drugs. The article also discusses the role of artificial intelligence in peptide design and the ongoing efforts to translate computational findings into effective clinical therapies.
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