Loss of ATP-Dependent Citrate Lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling

The authors investigate the role of ATP-dependent citrate lyase (ACL) in cardiac metabolism and its impact on left ventricular dysfunction in the context of nonischemic cardiomyopathy. They find that loss of ACL leads to altered cardiac metabolism, characterized by increased glucose uptake and impaired energy flux, ultimately contributing to left ventricular dysfunction. The study suggests that targeting citrate metabolism pathways could offer therapeutic strategies to improve cardiac function in heart failure.