Transforming Pulmonary Arterial Hypertension: Key Milestones and Future Perspectives

The authors aim to highlight the significant advancements in the understanding and treatment of pulmonary arterial hypertension (PAH) over the past four decades, while addressing ongoing challenges such as early diagnosis and personalized therapy. They discuss the multifaceted pathobiology of PAH, the emergence of new therapeutic options like sotatercept, and the importance of risk stratification in management. Despite progress, they emphasize the need for continued research to improve patient outcomes and quality of life.