July 9, 2026 · European heart journal · DOI: 10.1093/eurheartj/ehag482

Standardized endpoint definitions for trials of transcatheter left atrial appendage closure: a consensus from the Left Atrial Appendage Academic Research Consortium†

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The authors aimed to establish standardized endpoint definitions for trials of transcatheter left atrial appendage closure (LAAC) to enhance data collection, analysis, and reporting quality in this rapidly evolving field. By engaging a diverse group of experts and regulatory authorities, the Left Atrial Appendage Academic Research Consortium (LAARC) proposed consensus definitions for critical outcomes such as mortality, stroke, and device performance, with the goal of improving comparability across studies and supporting regulatory applications.

Philippe Garot, Roxana Mehran, Ole de Backer, James V Freeman, Nina Wunderlich, Benjamin Hibbert, Apostolos Tzikas, Devi Nair, Sergio Berti, Jacqueline Saw, Xavier Freixa, Shephal K Doshi, Ignacio Cruz-Gonzalez, Megan Coylewright, Adel Aminian, Matthew J Price, Lorenz Räber, Xiaoxi Yao, Laura Sanchis, Christian T Ruff, Ulf Landmesser, Dhanunjaya Lakkireddy, Christopher R Ellis, Mirvat Alasnag, Masanori Yamamoto, Enrico G Ferro, Shin Iwamoto, Takeshi Shiba, Yu Jin, Boris Schmidt, Vikrant Jagadeesan, Vivek Y Reddy, David Hildick-Smith, Angelo Oliva, Mitchell W Krucoff, Ernest Spitzer, Jens Erik Nielsen-Kudsk, C Michael Gibson, Edip M Gurol, Don E Cutlip, Martin B Leon, David R Holmes, Marie-Claude Morice, Mohamad Alkhouli

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Standardized endpoint definitions for trials of transcatheter left atrial appendage closure: a consensus from the Left Atrial Appendage Academic Research Consortium†

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