The dark genome in cardiovascular medicine
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The authors investigate the role of the 'dark genome'—non-coding DNA elements—in cardiovascular health and disease, aiming to elucidate how these components, particularly non-coding RNAs, regulate gene expression and influence disease susceptibility. They highlight recent advancements in genome analysis that have improved understanding of these elements and their potential for informing targeted therapeutics in cardiovascular medicine. The review emphasizes the emerging mechanistic insights that could lead to new strategies for prevention and management of cardiovascular diseases.
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